痹肿消汤治疗活动期类风湿关节炎的临床研究_梁清华.pdfVIP

2000,25(5) BULLHUNAN MED UNIV 449 梁清华, 唐 涛, 张花先, 刘 维, 范 荣 附属湘雅医院中西医结合研究所(长沙 410008) [ ] 对96例活动期类风湿关节炎( RA)病人采用痹肿消汤 疗与西药甲氨喋呤(MTX) 作对照研究结果表 明: 疗一月,痹肿消汤组的病人其晨僵关节疼痛关节肿胀关节压痛及关节功能障碍等主要症状与体征均较 前 显著改善( P 0.01或P 0.05) ;而MTX 组则无明显改善, 两组比较差异有显著性( P 0.01 或P 0.05) 疗三 月,上述主要症状与体征, 两组均较 前有显著改善( P 0.01 或P 0.05) , 但痹肿消汤组优于MTX 组ESR, CRP, RF,C3, IgG,IgA, IgM 等炎性及免疫指标 后两组均较 前明显降低( P 0. 01 或P 0. 05) ;痹肿消汤组的ESR,CRP 下降较MTX 组更明显, 更迅速痹肿消汤组, 临床 愈与显效率为78 ,总有效率为94 ;MTX 组, 临床 愈与显效 率为521 2 ,总有效率为87 ;痹肿消汤组显效率优于MTX 组( P 0. 05) 上述结果提示痹肿消汤改善RA 病人的 症状与体征,控制急性炎性反应优于MTX 组, 且较MTX 组作用更迅速;有与MTX 相类似的抗免疫作用, 且无明显的副 反应 [ ] 关节炎,类风湿性; 痹肿消汤; 甲氨喋呤; 药物疗法 [ ] R593122 [] A [ ] 1000-5625(2000)05-0449-04 Clinical investigation of effects of bizhongxiao decoction(BZX) on rheumatoid arthritis on active phase LIANG Qing-hua, TANGTao, ZHANG Hua-xian, et al I nstitute of Combined Traditi onal Chinese and Western M edicine , H unan Medical University ( Changsha 410008) [Abstract] Ninety-six patients with rheumatoid arthritis(RA) on active phase were divided into BZX- treatedgroup(BZXG) andmethotrexate-treatedgroup(MTXG). The results showedthat after 1-monthtreatment, symptoms andsigns, suchas joint tenderness, arthralgia, arthroncus, of patients in BZXG improvednotably( P 0.01or P 0.05), while those of patients in MTXGdid not improve, there was significant difference be- tween these two groups( P 0. 01orP 0.05) . After 3-monthtreatment, these symptomsandsignsimproved in both groups( P 0.01 or P 0.05) , but BZX had a better effect than MTX. ES