2种牙菌斑控制法对胃黏膜幽门螺杆菌再感染的影响研究.docVIP

2种牙菌斑控制法对胃黏膜幽门螺杆菌再感染的影响研究 2种牙菌斑控制法对胃黏膜幽门螺杆菌再感染的影响研究 作者：贾春玲 姜广水 杨学馨 窦慧琴 李翠荣 作者单位：1.山东大学齐鲁医院 口腔科；2.山东大学口腔医院 综合科；3.山东大学齐鲁医院 消化内科，山东 济南 250012 【摘要】 　目的 比较2种牙菌斑控制法对胃黏膜幽门螺杆菌（Ｈ.pylori）再感染率的影响，探讨Ｈ.pylori相关性胃病患者行菌斑控制的必要性及有效方法。方法 将148例胃炎和消化性溃疡患者随机分为试验一组（54例）、试验二组（55例）和对照组（39例），经消化内科抗Ｈ.pylori系统治疗并碳13尿素呼气试验证实Ｈ.pylori被根除后，试验一组行日常菌斑控制，试验二组除日常菌斑控制外增加牙菌斑的口腔专业处理，对照组未行上述处理。半年后行碳13尿素呼气试验检查确定各组胃黏膜Ｈ.pylori的感染率。结果 试验一组中5例患者因停用含漱液漱口被淘汰，试验二组中8例患者因未严格执行牙菌斑控制被淘汰。试验一组、试验二组、对照组患者Ｈ.pylori的感染率分别为67.3％、19.1％、82.1％。统计分析表明，试验二组患者Ｈ.pylori的感染率低于对照组、试验一组（?掊２＝33，P0.05；?掊２＝31.06，P0.05），试验一组患者Ｈ.pylori的感染率与对照组之间无统计学差异（?掊２＝2.43，0.1 【关键词】 菌斑控制 胃黏膜 幽门螺杆菌 　　Effects on Helicobacter pylori reinfection in gastric mucosa by two oral plaque control methods JIA Chun-ling1, JIANG Guang-shui2, YANG Xue-xin1, DOU Hui-qin1, LI Cui-rong3. （1. Dept. of Stomatology, Qilu Hospital of Shandong University, Jinan 250012, China; 2. Dept. of General Dentistry, Stomatological Hospital of Shandong University, Jinan 250012, China; 3. Dept. of Gastrointestinology, Qilu Hospital of Shandong University, Jinan 250012, China） 　　[Abstract] Objective To investigate the reinfection rate of Helicobacter pylori（H.pylori） in gastric mucosa by two measures of oral plaque control on patients, and to demonstrate the necessity and better method of plaque con-trol on those patients. Methods 148 patients suffered gastritis or gastroduodenal ulcer were assigned into test group 1（54 patients）, test group 2（55 patients） and control group（39 patients）. 13C-urea breath test proved that there were no H.pylori in their gastric mucosa. Daily plaque control was used in test group 1, oral professorial interventions were added into test group 2, neither daily plaque control nor oral professorial interventions was conducted in control group. All patients were conducted 13C-urea breath test again after half a year to determine the reinfection rate of H.pylori in gastric mucosa. Results 5 patients were eliminated because of