GCP对前列腺癌的作用.pdfVIP

THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE Volume 8, Number 4, 2002, pp. 493–497 © Mary Ann Liebert, Inc. CASE REPORT Regression of Prostate Cancer Following Administration of Genistein Combined Polysaccharide (GCP™), a Nutritional Supplement: A Case Report 1 1 MOHAMED A. GHAFAR, M.D., ERICA GOLLIDAY, M.A., 1 2 JONATHAN BINGHAM, M.D., MAHESH M. MANSUKHANI, M.D., ARISTOTELIS GEORGIOS ANASTASIADIS, M.D.,1,3 and AARON E. KATZ, M.D.3 ABSTRACT Purpose: It has been reported that genistein, an isoflavone used in soybeans, has antiprostate cancer effects. Genistein Combined Polysaccharide (GCP™; AMino Up, Sapporo, Japan), a nu- tritional supplement manufactured in Japan, is composed of genistein and a polysaccharide ob- tained from basidiomycetes (mycelia) that grows in a variety of mushrooms. Methods: We report a case of a patient with a biopsy proven prostate cancer showing clini- cal and pathologic evidence of regression following administration of GCP. The patient was en- rolled in an Institutional Review Board (IRB)-approved protocol and received GCP for 6 weeks prior to radical prostatectomy. Results: The patient’s prostate-specific antigen (PSA) decreased from an initial value of 19.7 to 4.2 ng/mL after 44 days of low-dose GCP. No cancer was identified in the radical prostatec- tomy specimen and no side effects were observed in this patient. Conclusion: This case suggests that GCP, which has shown potent inhibitory effects against prostate cancer in vitro, may have some potential activity in the treatment and prevention of prostate cancer. INTRODUCTION