康艾注射液联合TP方案治疗中晚期肺癌的临床观察.pdfVIP

· 1132 · MODERNONCOLOGY，Jun．2010，VO1．18，NO．6 康艾注射液联合TP方案治疗中晚期肺癌的临床观察 张锦林，杨 磊 ClinicalobservationofcombinedKangaiinjectionwithTPinthetreatmentofadvanced non——smallcelllungcancer zHANGJin—lin ．YANG Lei NantongTumorHospital，NantongUniversity，JiangsuNantong226361，China． 【Abstract】 OMective：ToobservetheefficacyandadversereactionsofKangaiinjectionpluspaclitaxelandeispla- tininthetreatmentofadvancednon—smallcel1lungcancer(NSCLC)．Methods：SixtycaseswithadvancedNSCLC wererandomlydividedintotwogroups，30patientsoftestrgoupweretreatedwithKangaiinjectioncombinedwithTP， 30patientsofcontrolrgoupwereonlytreatedwithTP．Thechemotherapyeffect．sideeffectsandimprovementofthe qualityofllfeoftwogroupswereevaluatedduringandafterchemotherapy．Res~ ：Thechemotherapyeffectoftest groupwashigherthantheother，butthedifferencewasnotstatisticallysignificant(P0．05)．Thetoxiciytreactions oftestgroupingastrointestinaltract，bonemalTow suppression，alopeciaandfatiguewerelowerthaninhtecontrol group，thedifferencewasstatisticallysignificant(P0．05)，thequalityoflife，Karnofskyscoreintestgroupin， creased，improvingratewas59．2％，thedifferencewasstatisticallysignificant(P0．05)．Conclusion：Kangaiin- jectioncomb inedwithTPinthetreatmentofnon—smallcelllungcancerhavebetterefficacy，caneffectivelyreduce toxicityandimprovequalityoflife． 【Keywords】Kangaiinjection；chemotherapy；non—smallcelllungcancer Modern Oncology2010，18(06)：1132—1134 【摘要】 目的：观察康艾注射液联合紫杉醇和顺铂治疗晚期非小细胞肺癌 (NSCLC)的临床疗效和不良反 应。方法：6o例中晚期NSCLC患者随机分为治疗组 (康艾注射液联合化疗组)3O例和对照组 (单纯化疗组) 3O例 ，评价2组患者化疗2个疗程后有效率、化疗期间及化疗后不 良反应及生存质量的改善情况。结果：治 疗组有效率优于对照组，但差异未达统计学意义 (P0．05)。治疗组不 良反应在 胃肠道反应、骨髓抑制、脱发 及疲劳方面均低于对照组，差异有统计学意义 (P0．05)。治疗组生存质量改善，卡氏评分提高，改善率达到 59．2％，两组比较差异有统计学意义(P0．05)。结论：康艾注射液联合TP方案治疗非小细胞肺癌有较好