晚期癌症患者姑息性镇静治疗现状.pdfVIP

》22010年第20卷第9期010年第20卷第9期 《 CCHINA ONCOLOGY HINA ONCOLOGY 22010 Vol.20 No.9010 Vol.20 No.9 669595 如何针对晚期癌症患者进行适当的镇静治疗，是姑息治疗领域的一个重要问题。 本研究旨在探索接受姑息治疗的晚期癌症患者的镇静治疗现状，以期更好的指导临床。回顾性分析2007 年3月—2009年5月复旦大学附属肿瘤医院姑息治疗科收治的患者中119例死亡病例的完整资料。其中患者的生 t 存期定义为入院时间至死亡时间，精确至天。应用Kaplan-Meier方法计算生存期，Log-rank检验差异性， 检 验及卡方检验比较接受及未接受镇静治疗患者的差异，logistic回归分析探索影响患者进行镇静治疗的因素。 P 以 0.05为检验标准。 119例患者中位生存时间为16 d。29例患者接受了姑息性镇静治疗，接受镇静与 P P 未接受镇静治疗的两组患者生存期差异无统计学意义。而谵妄（ 0.001）、呼吸困难（ =0.012）及睡眠倒 P 错（ =0.003）为影响是否进行镇静治疗抉择的因素。 本研究首次揭示了基于中国晚期癌症人群的镇静 治疗现状，证实了对于晚期癌症患者进行适当的镇静治疗的可行性，有益于姑息性镇静治疗的进一步开展。 　　姑息治疗；　镇静治疗；　生存期 　　R730.59　　A　　1007-3639(2010)09-0695-04 Palliative sedation for terminally ill cancer patients GU Xiao-li, CHENG Wen-wu (Department of Palliative Care, Cancer Center, Fudan University, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China) Correspondence to：CHENG Wen-wu　E-mail：cwwxmm@ 　　［Abstract ］ Background and purpose ：The process of administering sedation among palliative patients is an important part of palliative care. This study assessed sedation in terminally cancer patients in terms of three characteristics: the actual survival and sedation, the characteristic difference between patients who received sedation or not and the factors that infl uence the choice of sedation. Methods ：A retrospective analysis of the medical records of all 119 patients who were admitted and died at the Department of Palliative Care, Cancer Center, Fudan University between Mar. 2007 to May 2009 was performed. Data was collected, including demographic d