《3Nbutylphthalide improves neuronal morphology after chronic cerebral ischemia》.pdfVIP

NEURAL REGENERATION RESEARCH April 2014,Volume 9,Issue 7 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia Wanhong Zhao, Chao Luo, Jue Wang, Jian Gong, Bin Li, Yingxia Gong, Jun Wang, Hanqin Wang Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China Abstract Corresponding author: 3-N-butylphthalide is an effective drug for acute ischemic stroke. However, its effects on chronic Hanqin Wang, M.D., Ph.D., Institute of cerebral ischemia-induced neuronal injury remain poorly understood. Therefore, this study li- Basic Medical Sciences, Faculty of Basic gated bilateral carotid arteries in 15-month-old rats to simulate chronic cerebral ischemia in aged Medical Sciences, Hubei University of humans. Aged rats were then intragastrically administered 3-n-butylphthalide. 3-N-butylphtha- Medicine, Shiyan 442000, Hubei lide administration improved the neuronal morphology in the cerebral cortex and hippocampus Province, China, 117298088@. of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function. These doi: 10.4103/1673-5374.131576 findings suggest that 3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral / ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby im- proving cerebral neuronal injury and cognitive deficits. Accepted: 2014-02-24 Key Words: nerve regeneration; depression; functional MRI; graph theory; complex networks; brain