《70T nuclear magnetic resonance evaluation of the amyloid beta 140 animal model of Alzheimer’s diseasecomparison of cytology veriifcation》.pdfVIP

NEURAL REGENERATION RESEARCH February 2014,Volume 9,Issue 4 7.0T nuclear magnetic resonance evaluation of the amyloid beta (1–40) animal model of Alzheimer’s disease: comparison of cytology verification 1 2 3 4 Lei Zhang , Shuai Dong , Guixiang Zhao , Yu Ma 1 MR Neuroradiology Room, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, China 2 Department of Neurology, Sixth People’s Hospital of Jinan, Jinan, Shandong Province, China 3 Department of Rehabilitation Medicine, Sixth People’s Hospital of Jinan, Jinan, Shandong Province, China 4 Tsinghua University Yuquan Hospital, Beijing, China Abstract Corresponding author: 3.0T magnetic resonance spectroscopic imaging is a commonly used method in the research of Yu Ma, M.D., Tsinghua University Yuquan brain function in Alzheimer’s disease. However, the role of 7.0T high-field magnetic resonance Hospital, Beijing 100049, China, lymayu@163. spectroscopic imaging in brain function of Alzheimer’s disease remains unclear. In this study, com. 7.0T magnetic resonance spectroscopy showed that in the hippocampus of Alzheimer’s disease rats, the N-acetylaspartate wave crest was reduced, and the creatine and choline wave crest was doi:10.4103/1673-5374.128255 elevated. This finding was further supported by hematoxylin-eosin staining, which showed a loss / of hippocampal neurons and more glial cells. Moreover, electron microscopy showed neuronal shrinkage and mitochondrial rupture, and scanning electron microscopy revealed small size Accepted: 2013-11-25 hippocampal synaptic vesicles, inco