Sejnowski Influence of ionic conductances on spike timing reliability of cortical neurons f.pdf

J Neurophysiol 91: 194–205, 2004. First published September 24, 2003; 10.1152/jn.00556.2003. Influence of Ionic Conductances on Spike Timing Reliability of Cortical Neurons for Suprathreshold Rhythmic Inputs Susanne Schreiber,1,5 Jean-Marc Fellous,2 Paul Tiesinga,1,3 and Terrence J. Sejnowski1,2,4 1Sloan-Swartz Center for Theoretical Neurobiology, 2Howard Hughes Medical Institute, and Computational Neurobiology Lab, Salk Institute, La Jolla, California 92037; 3Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599; 4Department of Biology, University of California San Diego, La Jolla, California 92037; and 5Institute for Theoretical Biology, Humboldt-University Berlin, D-10115 Berlin, Germany Submitted 9 June 2003; accepted in final form 15 September 2003 Schreiber, Susanne, Jean-Marc Fellous, Paul Tiesinga, and Ter- respond more reliably to lower-frequency sinusoidal inputs rence J. Sejnowski. Influence of ionic conductances on spike timing (Fellous et al. 2001). An important difference between those reliability of cortical neurons for suprathreshold rhythmic inputs. J types of neurons is the composition of their ion channels. Neurophysiol 91: 194–205, 2004. First published September 24, Taking into account that effective numbers of ion channels can 2003; 10.1152/jn.00556.2003. Spike timing reliability of neuronal be adjusted on short time scales through neuromodulation, responses depends on the frequency content of the input. We inves- tigate how intrinsic properties of cortical neurons affect spike timing changes in ion channels may also provide a useful way for a reliability in response to rhythmic inputs of suprathreshold mean. neuron to dy