《Edaravone promotes functional recover y after mechanical peripheral nerve injury》.pdfVIP

NEURAL REGENERATION RESEARCH September 2014,Volume 9,Issue 18 Edaravone promotes functional recovery after mechanical peripheral nerve injury Teng Zhang, Zhengwei Li, Jianli Dong, Feng Nan, Tao Li, Qing Yu Department of Orthopedics, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China Abstract Corresponding author: Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. Feng Nan, M.D., Department of However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical Orthopedics, the Second Affiliated factors is unknown. In the present study, we established a peripheral nerve injury model by Hospital of Dalian Medical University, crushing the sciatic nerve using hemostatic forceps, and then administered edaravone 3 mg/kg Dalian 116023, Liaoning Province, China, intraperitoneally. The sciatic functional index and superoxide dismutase activity of the sciatic nanf1974@163.com. nerve were increased, and the malondialdehyde level was decreased in animals in the edaravone group compared with those in the model group. Bcl-2 expression was increased, but Bax expres- doi: 10.4103/1673-5374.141808 sion was decreased in anterior horn cells of the L4–6 spinal cord segments. These results indicated / that edaravone has a neuroprotective effect following peripheral nerve injury caused by mechan- ical factors through alleviating free radical damage to cells and inhibiting lipid peroxidation, as Accepted: 2014-07-17 well as regulating apoptosis-related protein expression. Key Words: ne