《Effects of nerve growth factor on the action potential duration and repolarizing currents in a rabbit model of myocardial infarction》.pdfVIP

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《Effects of nerve growth factor on the action potential duration and repolarizing currents in a rabbit model of myocardial infarction》.pdf

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Journal of Geriatric Cardiology (2013) 10: 39−51 ©2013 JGC All rights reserved; Research Article • Open Access • Effects of nerve growth factor on the action potential duration and repolariz- ing currents in a rabbit model of myocardial infarction 1 2 1 1 1 1 Yun-Feng Lan , Jian-Cheng Zhang , Jin-Lao Gao , Xue-Ping Wang , Zhou Fang , Yi-Cheng Fu , 2 2 1 1 Mei-Yan Chen , Min Lin , Qiao Xue , Yang Li 1 Institute of Geriatric Cardiology of Chinese PLA General Hospital, 28 Fuxing Road, 100853 Beijing, China 2Provincial Clinical Medicine College of Fujian Medical University, Fujian 350001, China Abstract Objectives To investigate the effect of nerve growth factor (NGF) on the action potential and potassium currents of non-infarcted myocardium in the myocardial infarcted rabbit model. Methods Rabbits with occlusion of the left anterior descending coronary artery were prepared and allowed to recover for eight weeks (healed myocardial infarction, HMI). During ligation surgery of the left coronary artery, a polyethylene tube was placed near the left stellate ganglion in the subcutis of the neck for the purpose of administering NGF 400 U/d for eight weeks (HMI + NGF group). Cardiomyocytes were isolated from regions of the non-infarcted left ventricular wall and the action poten- tials and ion currents in these cells were recorded using whole-cell patch clamps. Results Compared wi