鼻腔NKT细胞淋巴瘤的病理特征与诊断.pdfVIP

主圉垦至盎堡壁盘查!堂主!旦箜!鲞箜!塑 27 ·临床研究· 鼻腔NK／T细胞淋巴瘤的病理特征和诊断 李诗敏朱雄增王纾宜 killer 【摘要】 目的探讨鼻腔NK／T(naturalT)细胞淋巴瘤的临床病理特征以及其诊断和鉴别诊断。方法 收集62例原先诊断为鼻腔T细胞淋巴瘤的病例，观察其临床病理特点，并进行免疫组化检测LCA、CD45RO、 诊断为T细胞淋巴瘤。结论NK／T细胞淋巴瘤中CD56阳性率并非100％；石蜡切片中的CD3的阳性定位与T 细胞淋巴瘤定位不同；细胞毒性颗粒蛋白．T细胞内抗原(ⅡA-1)呈现高表达。以上3种抗体标记的联合使用可 提高该病的诊断率。(中国眼耳鼻喉科杂志，2007，7：27～28) 【关键词】鼻腔NK／T细胞淋巴瘤；免疫组织化学；病理特征；诊断 Featuresand ofNasalNK／T-Cell L／Shi·min，ZHU Pathological Diagnosis Lymphoma Xiong-zeng，WANGShu-yi Fudan 2003 1，China I却田伽琵mofPathology，EENTHospitalof University，Shanghai author：LI CorrespondingShi—min，E—mail：lishimin@163．con To the featuresofnasalNK／Tcell toelucidateits 【Abstract】Purpose studyclinicopathological lymphoma，and anddifferential Theclinicaldataof62caseswithnasalNK／Tcell were dia,gTloses diagnosis．Methods lymphomaanalyzed andthe ofLCA，CD45R0，CD3，L26，CD79a，CD56andTLAwereexaminedinthesecases． retrospectivelyexpressions nasal Results43Caseswere as NK／T-cell casesasT-cell Innasal diagnosed lymphoma．19 lymphoma．Conclusion of N辨cell ofCD56wasnot 10(3ationofthe reactiontoCD3 lymphoma，theimmunophenotypesalwayspositive；the positive NK／Tcell in sectionwasdifferentfromT-cell Was lymphomaparaffin lymphoma；eytotoxiegranuleprotein，11A·1highly ofthesethree wouldincrease rate．(ChinJ and expressed．Applicationantibodyexpressions diagnostic Ophthalmol Otorhinolaryngol，2007，7：27—28) NK／T．ceu words】nasal 【Key