槲皮素衍生物的合成方法及其血管舒展活性的研究.pdf

浙江大学硕士论文 素衍生物及类似物，观察它们与其它一些天然黄酮类化合物对大鼠离体胸主动脉 环的舒张作用，结果显示受试的黄酮类化合物可以浓度依赖性的舒张PE预收缩 的内皮完整的大鼠胸主动脉环，且其血管舒张活性随着其油水分配系数logP值 的增加而增大。 第三章：糖化学研究是目前药物化学的领域研究的热点之一。我们对糖保护 基及糖苷合成反应的研究进展进行了文献综述。 关键词：槲皮素衍生物合成血管的舒张作用油水分配系数 浙江人学硕士沦文 Abstract Thisdissertation consistsofthree chapters： 1：Flavonoidshavebeen toexhibitawide of Chapter reported rangebiological effects，including actions．In inhibit vasodilatoryaddition，flavonoidslipid the of aggregation，capillarypermeability，fragility,andactivityenzymesystems and isa includingcyclo—oxygenaselipoxygenase．Quercetinrepresentativeflavonols， whichexists innatureasits derivative．Itcontainsthe widely glycoside necessary structureforaflavonoltobe as inA active，such5，7dihydroxyring，Y,4’dihydroxy inB doublebondbetweenC2and ketone atthe C4． ring，the C3，a group position Therefore andits derivativeshavealmostallofthe that quercetinglycoside activity flavonolshave．Becausethenaturalsourcesarenotsuitableforresearchduetotheir aswellasthe to fromnatural complicated difficultygainpurepreparation products，it is to them method．We the necessarypreparebychemosynthesisdesignedsynthetic routeofthe targetcompounds： 1．The synthesisofquercetin-3-O-glycoside a．Rutinwasbe acidto thenketalwas Method hydrolysisby getquercetin，and obtained selective of witll through prote