抗菌肽的抗菌机制及其临床应用.pdfVIP

微生物学通报 JAN 20, 2009, 36(1): 97~105 Microbiology © 2009 by Institute of Microbiology, CAS tongbao@ 专论与综述 抗菌肽的抗菌机制及其临床应用 * 侯晓姝 胡宗利 陈国平 李 勇 王炳琴 李栀恩 ( 400030) : , , 摘 要 抗菌肽是广泛存在于生物体内的一种小分子肽 具有广谱性、高效性、稳定性等特点 其 本身不易产生耐药性。不仅具有杀菌作用, 还能抑杀真菌、寄生虫、病毒以及肿瘤细胞且对正常 细胞毒性较小。新颖抗生素发现的缺乏, 导致了大量耐药菌株的出现, 抗菌肽有可能成为一种新 的抗生素替代品。本文介绍了抗菌肽的结构特点、生物活性, 并重点阐述了其抗菌机制及最新临 床应用进展。 关键词: 抗菌肽, 抗菌机制, 临床应用 Antimicrobial Peptides: Antibacterial Mechanism and Therapeutic Use * HOU Xiao-Shu HU Zong-Li CHEN Guo-Ping LI Yong WANG Bing-Qin LI Zhi-En (Bioengineering College of ChongQing University, Chongqing 400030, China) Abstract: Antimicrobial peptides, a cluster of small peptides secreted by the majority of creatures, have been demonstrated with activity against a wide range of microorganisms including bacteria, protozoa, yeast, fungi, viruses and even tumor cells. These peptides have some features such as broad spectrum , high effi- cacy and stability, little drug resistance. A lack of new antibiotics combined with emerging multi-drug resis- tance issues demands that new antimicrobial strategies be explored for treating these infections. It has been proposed that the antimicrobial peptides might form the foundation for a new class of clinically useful an- timicrobials. We review the advantages of these molecul