原创力文档Pyrolysis Mass Spectrometry A Predictor of Clinical Response to Treatment in Pulmonary Opportunist Mycobacterial Infection Preliminary Work with M. malmoense》.pdf
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Pyrolysis Mass Spectrometry A Predictor of Clinical Response to Treatment in Pulmonary Opportunist Mycobacterial Infection Preliminary Work with M. malmoense》.pdf
Zbl. Bakt. 285, 291-298 (1996)
© Gustav Fischer Verlag, Jena
Pyrolysis Mass Spectrometry: A Predictor of Clinical Response
to Treatment in Pulmonary Opportunist Mycobacterial
Infection: Preliminary Work with M. malmoense
M. L. HEGINBOTHOM and J. T. MAGEE
Department of Medical Microbiology and Public Health Laboratory, University Hospital
of Wales, Cardiff, UK
Summary
Pyrolysis mass spectrometry (Py-MS) yields data reflecting overall cell composition. The
changes in composition induced by treatment with rifampicin and ethambutol, alone and
in combination, were investigated for a collection of seven strains of Mycobacterium mal-
moense from pulmonary infections. Two strains, both from patients that had responded to
therapy with this combination, showed large changes in composition from control, un-
treated cultures. The difference was particularly marked for the ethambutol treated cultures.
Four strains, all from patients who had failed to respond to therapy with this combination,
showed minimal changes in composition for all treatments. The remaining strain also show-
ed minimal treatment-induced change, but, for this patient, therapy with the combination
had proved successful. Minimum inhibitory concentrations (MICs) were determined radio-
metrically. All strains showed MICs 0.5 !J.glmL for rifampicin (sensitive) and of 8 !J.glmL
for ethambutol (resistant). MIC results did not correlate with clinical response, whereas the
Py-MS results correlated with clinical response for six of the seven isolates. Py-MS may have
a role in predicting effective therapy for this problem group.
Introduction
Opportunist mycobacteria are a recognised cause of pulmonary disease (5, 8, 29,
30, 33, 36, 37), the treatment of which requires a combination of antimycobacterial
agents. The combination of agents combats the emergence of resistant mutants, and
targets distinct portions of the heterogeneous bacterial popul
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