原创力文档Quercetin inhibits the mTORC1p70S6K signaling-mediated renal tubular epithelial–mesenchymal transition and renal fibrosis in diabetic nephropathy》.pdf
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Quercetin inhibits the mTORC1p70S6K signaling-mediated renal tubular epithelial–mesenchymal transition and renal fibrosis in diabetic nephropathy》.pdf
Pharmacological Research 99 (2015) 237–247
Contents lists available at ScienceDirect
Pharmacological Research
j o u rn al h omepage: w w w. elsev /locate/yphrs
Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal
tubular epithelial–mesenchymal transition and renal fibrosis
in diabetic nephropathy
Qian Lu 1, Xiao-Jun Ji 1, Yue-Xian Zhou, Xiao-Qin Yao, Yu-Qing Liu, Fan Zhang,
Xiao-Xing Yin ∗
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical College, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China
a r t i c l e i n f o a b s t r a c t
Article history: Quercetin is a classic flavonoid that inhibits the epithelial–mesenchymal transition (EMT) of tumor cells.
Received 12 February 2015 However, the effects of quercetin on the EMT of renal tubular epithelial cells, a potential mechanism of
Received in revised form 14 June 2015 renal fibrosis and important characteristic of diabetic nephropathy (DN), remain largely unknown. In the
Accepted 14 June 2015
present study, we investigated the effects of quercetin on the EMT of two lines of renal tubular proximal
Available online 4 July 2015
epithelial cells (HK-2 and NRK-52E) induced with high glucose and renal fibrosis resulting from type 1
diabetes and tried to clarify the specific mechanisms underlying these effects. The in vitro results showed
Keywords:
that the EMT of HK-2 and NRK-52E cells was induce
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