Reductive alkylation of hyaluronic acid for the synthesis of biocompatible hydrogels by click chemistry》.pdf
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Reductive alkylation of hyaluronic acid for the synthesis of biocompatible hydrogels by click chemistry》.pdf
Carbohydrate Polymers 90 (2012) 1704–1711
Contents lists available at SciVerse ScienceDirect
Carbohydrate Polymers
j o u r na l h o me p a g e : w w w. elsev /locate/car bpol
Reductive alkylation of hyaluronic acid for the synthesis of biocompatible
hydrogels by click chemistry
∗
ˇ
Gloria Huerta-Angeles ˇ ˇ
, Miroslava Nemcová, Eva Príkopová, Daniela Smejkalová, Martin Pravda,
ˇ ˇ ´
Lukás Kucera, Vladimír Velebny
Contipro Biotech, Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic
ˇ ˇ
a r t i c l e i n f o a b s t r a c t
Article history: Hyaluronan (HA) based hydrogels have been synthesized combining chemical modification of the
Received 10 May 2012 polysaccharide by partial oxidation, reductive amination and ‘click chemistry’. HA was oxidized by
Received in revised form 20 June 2012 4-acetamido-TEMPO-mediated reaction, using sodium hypochlorite as primary oxidant and NaBr in
Accepted 2 July 2012 buffered pH, so that the produced aldehyde moieties (hemiacetals) were trapped in situ by adding primary
Available online 28 July 2012
amines containing azide or alkyne-terminal groups. The structure of the reaction products, oxidized-HA
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