《光子束和电子束在早期乳腺癌患者放疗瘤床加量计划的剂量学研究（英文）》.pdfVIP

Chinese-German Journal of Clinical Oncology December 2012, Vol. 11, No. 12, P710–P715 DOI 10.1007/s10330-012-1086-6 Dosimetric study comparing photon and electron beams for boosting the tumor bed in early-stage breast cancer 1 2 1, 2 2 2 Mohamed Mahmoud , Soha Ahmed , Ehab M. Attalla , Hassan S. Abouelenein , Shaimaa Shoier , Mohsen Barsoum1 1 Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt 2 Radiation Oncology Department, Children’s Cancer Hospital, Cairo, Egypt Received: 11 September 2012 / Revised: 2 October 2012 / Accepted: 5 November 2012 © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2012 Abstract Objective: The aim of our study was to assess and compare the potential dosimetric advantages and drawbacks of photon beams and electron beams as a boost for the tumor bed in superficial and deep seated early-stage breast cancer. Methods: We planned CTs of 10 women with early breast cancer underwent breast conservative surgery were selected. Tumor bed was defined as superficial and deep with a cut of point 4 cm, those with less than 4 cm were defined as superficial tumors representing 4 patients and those with depth of 4 cm or more were classified as deep tumors representing 6 patients. The clinical target volume (CTV) was defined as the area of architectural distortion surrounded by surgical clips. The plan- ning target volume (PTV) was the CTV plus margin 1 cm. A dose of 10 Gy in 2 Gy fractions was given concurrently at the last week of treatment. Organs at risk (OARs) wer