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II
曲阜师范大学2007级硕士论文
Abstract
Tuberculosisisa infectiousdiseasewhichthreatshumanhealth.Duethe
major to
of strainsof andcure
tuberculosis,TB
multipledrug-resistantMycobacterium prevention
becometroublesome itis tofmdand newanti-TBto
increasingly,andimperative develop drugs
shortentreatmenttimeandkill resistanttuberclebacillus.Thesenew musthave
multidrug drugs
the effectiveanti-tuberculosis effecton
following
characteristics:(1)highly activity.(2)Killing
resistant andthe
multi—drug strainsof sideeffects inductionof
TB.(3)without
strains.
砀e of and of have forthe
discoveryphagestudybacteriophageLysinsbroughthope
treatmentof tuberculosisinfection.At researchof
drug—resistantMycobacterium present,the
isstillin athomeand some
mycobacteriophageLysins earlystages abroad.Although
havebeen havenotbeen
genomes sequenced,theirlysingenes
myeobacteriophage
D29a whichinfectand
is lytic Can M.tuberculosisand
bacteriophage destroy
Amino
acid showsthatD29
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