《BARTONELLOSIS THE HIDDEN》.pdf

BARTONELLOSIS: THE HIDDEN EPIDEMIC! Edward B. Breitschwerdt, DVM Professor of Medicine and Infectious Diseases CENTER FOR COMPARATIVE MEDICINE AND TRANSLATIONAL RESEARCH North Carolina State University College of Veterinary Medicine DISCLOSURES-2010 • Chief Scientific Officer-Galaxy Diagnostics • Vector-Borne Diseases Diagnostic Laboratory, NCSU • NCSU Biosafety Level III Laboratory • Scientific Consultant-IDEXX and Abbott Laboratories • Research Funding-Numerous Industry Sources RESEARCH FUNDING 2008-2010 • ACVIM FOUNDATION • AMERICAN KENNEL CLUB • BAYER ANIMAL HEALTH • FORT DOGE ANIMAL HEALTH • IDEXX LABORATORIES • KINDY FRENCH FOUNDATION • SIGMON TRUST FUND • NOVARTIS ANIMAL HEALTH • STATE OF NORTH CAROLINA • WALTHAM BARTONELLA SPECIES •Gram negative, short pleomorphic rods • Family: BARTONELLACEAE Order: Rhizobiales ●Class: Alpha Proteobacteria • Fastidious: Division time 22-24 hrs •Cellular targets: •Erythrocytes •Endothelial Cells •Microglia Cells •Macrophages •CD34 Progenitor Cells Kordick DL, Breitschwerdt EB: JCM 1999 100 Ehrlichia canis Oklahoma 50 Ehrlichia canis VDE 100 Ehrlichia chaffeensis 100 Ehrlichia muris 66 Ehrlichia ruminantium Neorickettsia helminthoeca