《btg1010.tex-BIOINFORMATICS》.pdfVIP

BIOINFORMATICS Vol. 19 Suppl. 1 2003, pages i84–i90 DOI: 10.1093/bioinformatics/btg1010 Combining multiple microarray studies and modeling interstudy variation 1, 2 2 2 Jung Kyoon Choi , Ungsik Yu , Sangsoo Kim and Ook Joon Yoo 1,∗ 1Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 371-1 Guseong-dong Yuseong-gu, Daejeon 305-701, Korea and 2 Genome Research Center, Korea Research Institute of Bioscience and Biotechnology, Oun-dong 52 Yuseong-gu, Daejeon 305-333, Korea Received on January 6, 2003; accepted on February 20, 2003 ABSTRACT combine results of individual studies. For this purpose, We have established a method for systematic integration Rhodes et al. (2002) recently applied a meta-analytic of multiple microarray datasets. The method was applied approach to microarrays. Here we introduce the most to two different sets of cancer profiling studies. The change developed meta-analytic method, which expresses the of gene expression in cancer was expressed as ’effect result in the form of effect size. size’, a standardized index measuring the magnitude of An effect size approach has desi