原创力文档A New FRET-Based Sensitive DNA Sensor for Medical Diagnostics using PNA Probe and Water-Soluble Blue Light Emitting Polymer.pdfVIP
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A New FRET-Based Sensitive DNA Sensor for Medical Diagnostics using PNA Probe and Water-Soluble Blue Light Emitting Polymer.pdf
Hindawi Publishing Corporation
Journal of Sensors
Volume 2008, Article ID 270475, 6 pages
doi:10.1155/2008/270475
Research Article
A New FRET-Based Sensitive DNA Sensor for
Medical Diagnostics using PNA Probe and Water-Soluble
Blue Light Emitting Polymer
Nidhi Mathur, Anamika Aneja, P. K. Bhatnagar, and P. C. Mathur
Department of Electronic Science, University of Delhi South Campus, Benito Juarez Road, New Delhi-110021, India
Correspondence should be addressed to Anamika Aneja, anamica 30@yahoo.co.in
Received 2 January 2008; Revised 4 April 2008; Accepted 3 June 2008
Recommended by Mike McShane
A reliable, fast, and low-cost biosensor for medical diagnostics using DNA sequence detection has been developed and tested for
the detection of the bacterium “Bacillus anthracis.” In this sensor, Poly [9,9-di (6,6 - N, N trimethylammonium) hexylfluorenyl-2,
7-diyl)-alt-co- (1,4-phenylene)] dibromide salt (PFP) has been taken as cationic conjugated polymer (CCP) and PNA attached
with fluorescein dye (PNAC∗) as a probe. The basic principle of this sensor is that when a PNAC∗ probe is hybridized with a single
strand DNA (ssDNA) having complementary sequence, Forster resonance energy transfer (FRET) may take place from PFP to
the PNAC∗/DNA complex. If the FRET is efficient, the photoluminescence from the PFP will be highly quenched and that from
PNAC∗ will be enhanced. On the other hand, if the DNA sequence is noncomplementary to PNA, FRET will not occur.
Copyright © 2008 Nidhi Mathur et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
1. INTRODUCTION that have found use in a variety o
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