An In Silico Approach for Evaluating a Fraction-Based, Risk Assessment Method for Total Petroleum Hydrocarbon Mixtures.pdfVIP

Hindawi Publishing Corporation Journal of Toxicology Volume 2012, Article ID 410143, 8 pages doi:10.1155/2012/410143 Research Article An In Silico Approach for Evaluating a Fraction-Based, Risk Assessment Method for Total Petroleum Hydrocarbon Mixtures Nina Ching Y. Wang,1 Glenn E. Rice,1 Linda K. Teuschler,1 Joan Colman,2 and Raymond S. H. Yang3 1 National Center for Environmental Assessment, Offi ce of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH 45268, USA 2 Chemical, Biological and Environmental Center, SRC, Inc., Syracuse, NY 13212, USA 3 Quantitative and Computational Toxicology Group, Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA Correspondence should be addressed to Nina Ching Y. Wang, wang.nina@ Received 25 August 2011; Accepted 1 November 2011 Academic Editor: Marina V. Evans Copyright © 2012 Nina Ching Y. Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Both the Massachusetts Department of Environmental Protection (MADEP) and the Total Petroleum Hydrocarbon Criteria Working Group (TPHCWG) developed fraction-based approaches for assessing human health risks posed by total petroleum hydrocarbon (TPH) mixtures in the environment. Both organizations defined TPH fractions based on their expected environmental fate and by analytical chemical methods. They derived toxicity values for selected compounds within each fraction and used these as surrogates to assess hazard or risk