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An NMR Study of the Bortezomib Degradation under Clinical Use Conditions.pdf
Hindawi Publishing Corporation
Advances in Hematology
Volume 2009, Article ID 704928, 5 pages
doi:10.1155/2009/704928
Research Article
An NMR Study of the Bortezomib Degradation under Clinical
Use Conditions
Adele Bolognese,1 Anna Esposito,1 Michele Manfra,1 Lucio Catalano,2
Fara Petruzziello,2 Maria Carmen Martorelli,2 Raffaella Pagliuca,3
Vittoria Mazzarelli,3 Maria Ottiero,3 Melania Scalfaro,3 and Bruno Rotoli2
1 Dipartimento di Chimica Organica e Biochimica, Universita Degli Studi di Napoli Federico II, Via Cynthia 6, Monte Sant’Angelo,
`
80126 Napoli, Italy
2 Dipartimento di Biochimica e Biotecnologie Mediche, Divisione di Ematologia, Universita Degli Studi di Napoli Federico II,
`
80131 Napoli, Italy
3 Farmacia Centralizzata, Azienda Ospedaliera, Universitaria “Federico II”, 80131 Napoli, Italy
Correspondence should be addressed to Adele Bolognese, bologne@unina.it
Received 14 November 2008; Accepted 9 February 2009
Recommended by David H. Vesole
The (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl-boronic acid, bortezomib (BTZ), which
binds the 20S proteasome subunit and causes a large inhibition of its activity, is a peptidomimetic boronic drug mainly used
for the treatment of multiple myeloma. Commercial BTZ, stabilized as mannitol derivative, has been investigated under the
common conditions of the clinical use because it is suspected to be easily degradable in the region of its boronic moiety.
Commercial BTZ samples, reconstituted according to the reported commercial instructio
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