Correlation between Animal and Mathematical Models for Prostate Cancer Progression.pdfVIP

Computational and Mathematical Methods in Medicine Vol. 10, No. 4, December 2009, 241–252 Correlation between animal and mathematical models for prostate cancer progression Z. Jackiewicza1, C.L. Jorcykb2, M. Kolevc3 and B. Zubik-Kowald4* aDepartment of Mathematics and Statistics, Arizona State University, Tempe, AZ, USA; bDepartment of Biology, Boise State University, Boise, ID, USA; cDepartment of Mathematics and Computer Science, University of Warmia and Mazury, Olsztyn, Poland; dDepartment of Mathematics, Boise State University, Boise, ID, USA ( Received 26 October 2007; final version received 30 May 2008 ) This work demonstrates that prostate tumour progression in vivo can be analysed by using solutions of a mathematical model supplemented by initial conditions chosen according to growth rates of cell lines in vitro. The mathematical model is investigated and solved numerically. Its numerical solutions are compared with experimental data from animal models. The numerical results confirm the experimental results with the growth rates in vivo. Keywords: prostate tumour progression; growth rates of Pr-cell lines in vitro; animal models for prostate cancer; growth rates in vivo; mathematical model; numerical simulations AMS Subject Classification: 45K05; 34K28; 62P10 1. Introduction The purpose of this paper is to analyse the C3(1)/Tag-Pr cell lines introduced in Refs. [7,12,24] and to develop a mathematical model which has a potential to describe the growth rates of Pr-cell lines in vivo. We have shown that the numerical solutions of the mathematical model can be used to predict the behaviour of the cancer cell (CC) populations in vivo. Mathematical models of cancer growth have been the subject