Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy.pdfVIP

Hindawi Publishing Corporation Journal of Transplantation Volume 2010, Article ID 719696, 13 pages doi:10.1155/2010/719696 Research Article Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy Khurram Shahzad,1 Martin Cadeiras,2 Sarfaraz Memon,1 Barry Zeeberg,3 Tod Klingler,4 Anshu Sinha,1 Esteban G. Tabak,5 Sreevalsa Unniachan,1 and Mario C. Deng1, 6 1 Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA 2 Division of Cardiology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA 3 Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 4 XDx Inc., Brisbane, CA 94005, USA 5 Courant Institute of Mathematical Science, New York University, New York, NY 10012, USA 6 Cardiac Transplantation Research, Center for Advanced Cardiac Care, Columbia University College of Physicians Surgeons, New York Presbyterian Hospital, PH Room 1291, 622 W 168th Street, New York, NY 10032, USA Correspondence should be addressed to Mario C. Deng, md785@ Received 27 June 2010; Revised 18 September 2010; Accepted 27 September 2010 Academic Editor: Kazuhiko Yamada Copyright © 2010 Khurram Shahzad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Cardiac allograft vasculopathy (CAV) is a major cause of graft loss and death after heart transplantation. Currently, no d