Identification of Risk Factors for Vascular Thrombosis May Reduce Early Renal Graft Loss A Review of Recent Literature.pdfVIP

Hindawi Publishing Corporation Journal of Transplantation Volume 2012, Article ID 793461, 9 pages doi:10.1155/2012/793461 Review Article Identification of Risk Factors for Vascular Thrombosis May Reduce Early Renal Graft Loss: A Review of Recent Literature Anna Krarup Keller,1, 2 Troels Munch Jorgensen,2 and Bente Jespersen3 1 Institute of Clinical Medicine, Aarhus University, Denmark 2 Department of Urology, Aarhus University Hospital, Brendstrupgaardsvej 100, Skejby, 8200 Aarhus N, Denmark 3 Department of Nephrology, Aarhus University Hospital, Brendstrupgaardsvej 100, Skejby, 8200 Aarhus N, Denmark Correspondence should be addressed to Anna Krarup Keller, anna.keller@ki.au.dk Received 21 February 2012; Accepted 8 April 2012 Academic Editor: Gian Luigi Adani Copyright © 2012 Anna Krarup Keller et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Renal graft survival has improved over the past years, mainly owing to better immunosuppression. Vascular thrombosis, though rare, therefore accounts for up to one third of early graft loss. We assess current literature on transplantation, identify thrombosis risk factors, and discuss means of avoiding thrombotic events and saving thrombosed grafts. The incidence of arterial thrombosis was reported to 0.2–7.5% and venous thrombosis 0.1–8.2%, with the highest incidence among children and infants, and the lowest in living donor reports. The most significant risk factors for developing thrombosis were donor-age below 6 or above 60 years, or recipient-age below 5-6 years, per- or postoperative hemodynamic instability, peritoneal dialysis, diabetic nephropathy, a his