Nucleocytoplasmic Trafficking of G2M Regulators in Yeast.PDFVIP

Molecular Biology of the Cell Vol. 19, 4006–4018, September 2008 Nucleocytoplasmic Trafficking of G2/M Regulators in Yeast Mignon A. Keaton,* Lee Szkotnicki, Aron R. Marquitz,† Jake Harrison,‡ Trevin R. Zyla,§ and Daniel J. Lew Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710 Submitted March 17, 2008; Revised June 5, 2008; Accepted June 9, 2008 Monitoring Editor: Mark J. Solomon Nucleocytoplasmic shuttling is prevalent among many cell cycle regulators controlling the G2/M transition. Shuttling of cyclin/cyclin-dependent kinase (CDK) c