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JOINT SOGC–CCMG COMMITTEE OPINION
JOINT SOGC–CCMG COMMITTEE OPINION
No. 216, September 2008
Fragile X Testing in Obstetrics and Gynaecology
in Canada
Abstract
This committee opinion has been prepared by the Genetics Objective: To provide Canadian family physicians, genetic
Committee of the Society of Obstetricians and Gynaecologists of counsellors, medical geneticists, midwives, and
Canada (SOGC) and the Prenatal Diagnosis Committee of the obstetrician-gynaecologists with recommendations regarding
Canadian College of Medical Geneticists (CCMG) and approved screening for fragile X in the obstetrical and gynaecological
by the Executive of the SOGC and the Board of Directors of the population.
CCMG.
Methods: Medline, the Cochrane Library, journals, and textbooks
PRINCIPAL AUTHORS were searched for English-language articles, published between
David Chitayat, MD, Toronto ON 1966 and March 2008, relating to fragile X testing outcomes.
Search terms included fragile X, screening, prenatal testing,
Philip R. Wyatt, MD, Toronto ON pregnancy outcome, premutation, trinucleotide repeats, and
SOCIETY OF OBSTETRICIANS AND GYNAECOLOGISTS OF ovarian failure. All study types were reviewed. Randomized
CANADA GE
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