急性白血病患者清vegf和ldh水平的测定及临床意义.pdfVIP

捅 要 盟检测急性自血病 AL 不同类型及不同阶段血清斑管内皮生长因子 vascular endothelial growthfactor，VEGr9和乳酸脱氢酶 1actate 者间关系及其在AL的病情监测、疗效观察及预后判断中的意义。 虚蘧 选取魅患者稻铡，其中初诊患者25铡，复发罐治患者勰德，28铡健康者 作为正常对照，分别用酶联免疫 EUSA 法测定患者血清VEGF，用速率法测定其赢清LDH 含量。所有数据均采用SPSSl3．0统计软件分析处理。 细胞计数 wBc 及m红蛋白∞ 含量均无相关。 箜主鼓 初诊A己患者盘清VEGF及LDH水平魄显高予对照组，宠全缓解盛恢复至接 近正常，复发时再次升高，外周血ⅦGF和LDH水平与白觑病治疗疗效均呈正相关，故动 态检测血清VEGF及LDH水平可在一定程度上了解AL病情，对AL的疗效及预后判断有 一定的指导意义。 VEGF，LDH， 关键词 急性白血病， 临床意义 Abstract measuretheserumvascularendothelialfactor VEGF andlactate 星坠￡艘墼To growth inacuteleukemia differentandto the samples硒|lltypes explore dehydrogenase 醢H levels betweenserum levelsandcurativeeffectsinacuteleukemia relationship VEGF,LDH patients． casesofacuteleukemia 25casesof leukemia ．M．．．．e．。t。．h．．．o．．d．．．s．．．45 patientsincluding primary of casesof and enrolledinthis levels refractory study．Serum patients，20relapse patients，were VEGFandLDHweredetected immunoabsorbent automatic byenzyme-linked assay【ELISA】and VEGFandLDHlevelsinthevarious ofacuteleukemiawere analyzer．The subtypes patients and contrastedtothoseofcontrol betweenthe levels the VEGF，LDH groups．relationship cellswithinnucleatedcellsInbonemarrowandotherrelateditemswerealso numbersoftheblast datawere SPSSl3．0．PValueslessthanO．05wereconsideredtobe analyzed．All analyzedby statisticallysignificant． levels AL were VEGF —Resu—lts 1 Serumof咖afy than ofnormal andthedifferenceswere higherobviouslythose 59．45_+20．20 pg／mLsubjects LDHlevelsof AL statisticallysignificant p 0．01 ，serumprimary the were than normal and differences those 141．07_+40．11 肌ofsubjects they higherobviously were levelswerereduced inthe statisticallysignificant◇《o．01 ．VEGF to 78．87_+17．66 pg／mL AL with remission，no differencestothecontrol patientscomplete statisticallysignificant LDHlevelswerereduced significant group p 0．05 ，and to 215．72±74．13 IU／L·nostatistically differencestothecontrol VEGFlevelsof inCR group p 0．05 ．Serumpretreatmentpatientsgroup thoseofNit VEGFlevelsof were 131．48_+40．76 pg／mL,serum