上皮间质转化和恶性肿瘤转移_英文_.pdfVIP

Chinese-German Journal of Clinical Oncology March 2011, Vol. 10, No. 3, P125–P133 DOI 10.1007/s10330-011-0740-8 Epithelial-mesenchymal transition and cancermetastasis* Junjian Deng, Ximing Xu Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China Received: 16 November 2010 / Revised: 10 December 2010 / Accepted: 25 January 2011 © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2011 Abstract Epithelial-mesenchymal transition (EMT) is initially considered as a physiological phenomenon during the em- bryogenesis of mammals, as well as a basic biological event maintaining the stability of the vital body. Recent researches in- dicated that EMT plays a critical role in various tumors progression, through which epithelial cancers invade and metastasize. The cell characteristics are changed during EMT, in which the cells lose cell-cell and cell-matrix interactions and apical polarity, reorganize their cytoskeleton, and become isolated, motile, as well as resistant to anoikis, then become spindle-shaped mes- enchymal cells. This review lays emphasis on studying the cell morphogenesis, makers and molecular mechanism regulation about EMT, discussing the relationship between the EMT and the cancer development and metastasis. Key words EMT; molecular mechanism; cancer; metastasis In cancer, EMT has been observed in breast [1], ovar- The transformation of cell morphology ian [2], colon [3], and esophageal [4] cancer models. As we and EMT-associate markers known, epithelia cells are considered as terminal differ- entiation cells for a long time, having protective effects Upon EMT, apical-basal cell polarity is lost, with the in mature individual. Epithelia c