化瘀消疕饮合走法治疗斑块型银屑病的临床研究及对tnf-α、il-8的影响.pdfVIP

HuaYuxiaobi decoction taken orally with the cutem and Calcipotriol in Treating plaque Psoriasis Vulgaris and Detection of TNF-α and IL-8 Speciality： Dermatology ，Surgery of TCM Auther ： Wan Shanshan Tuter： Professor Geng Lidong Abstract Objective：To observe the clinical efficacy of HuaYuxiaobi decoction combined with cutem and the external use of Calcipotriol in treatment of plaque psoriasis vulgaris and to investigate the possible mechanisms and the function of TNF-α and IL-8 in the pathogenesis of PV. Methods ：30 patients with plaque psoriasis vulgaris had received the HY combined with cutem and the external use of Calcipotriol for 12 weeks，compared with the other 30 received XiaoYin tablets and FuFangdanshen tablets and the external use of Calcipotriol. Measure the level of serum TNF-α and IL-8 before and after the treatment. Results ：The clinical cure and obvious rate was 70.00%，the effective rate was 93.33% ， the control group were 40.00% and 76.67%. As to the recrudescent rate and the side-effective rate，there were significant differences between the two groups. The level of serum TNF-α and IL-8 decreased obviously after the treatment. Conclusions：HY is effective in the treatment of plaque PV. The possible mechanisms of its action might be to be adjust the level of serum TNF-α and IL-8.Combined with cutum can promote the gradually vanish of cutaneous lesion，and then enhance the curative effect and short the treatment. Key words plaque psoriasis vulgaris ；cutem ；Clinical ；TNF-α；IL-8 目 录 引 言 1 临床研究 2 一、一般资料 2 二、诊断标准 3 （一）西医诊断标准 3 （二）中医辨证标准 3 （三）临床分期标准 4 三、纳入病例标准 4 四、排除病例标准 4 五、治疗方法 4 （一）药物及用药方法 4 （二）疗