CXCR4和VEGF-C在乳腺癌组织中表达及淋巴结转移之间关系.docVIP

CXCR4和VEGF-C在乳腺癌组织中的表达 及与淋巴结转移之间的关系 黄天从 许建华 叶凯 　 (福建医科大学附属第二医院外科,福建 362000) 　　【摘要】 目的　探讨趋化因子受体(CXCR4)和血管内皮生长因子C(VEGF-C)在人乳腺癌组织中的表达及与淋巴结转移之间的关系。方法　选择65例乳腺癌标本,应用免疫组织化学染色方法,检测CXCR4和VEGF-C在人乳腺癌组织中的表达,同时对其与临床病理参数的关系进行统计学分析。结果　CXCR4在乳腺癌组织中的阳性表达率为43. 1%,其中淋巴结转移组表达率为57. 9%,无淋巴结转移组表达率为22. 2%,差异有非常显著的统计学意义(P0.01)。VEGF-C在乳腺癌组织中的阳性表达率为50. 2%,其中淋巴结转移组表达率为68. 4%,无淋巴结转移组表达率为25. 9%,二者差异非常显著(P0·01)。而且,CXCR4阳性表达与VEGF-C阳性表达呈显著正相关(P0·05)。乳腺癌CXCR4和VEGF-C的表达水平与乳腺癌淋巴结转移密切相关,而与病人的月经状态、临床分期、病理类型等无相关性(P0.05)。结论　CXCR4和VEGF-C的表达可作为评估乳腺癌病人淋巴道转移的一个观测指标。 【关键词】趋化因子受体; 血管内皮生长因子C; 乳腺肿瘤; 淋巴道转移 【中图分类号】R 737. 9　　　【文献标识码】A　　　【文章编号】 Correlation of CXCR4 and VEGF-C expressionswith lymph nodemetastasis in breast carcinoma Huang Tian Cong, Xu Jian Hua, Ye Kai (Department of Surgery, Second Affiliated Hospital of Fujian Medical University,Fujian362000,China) 　　【Abstract】 Objective　To investigate the relationship of the expressionsofchemokine receptorCXCR4 andvascular endothelial growth factor C(VEGF-C)with lymph node metastasis in breast carcinoma.Methods　Immuohistochemistry was used to detect the expressions ofCXCR4 and VEGF-C in 65 samples ofbreast carcinoma. The relationship between CXCR4 and VEGF-C expressions and the clinicpathological di-ammeters was statistically analyzed. Results　The positive rate ofCXCR4 expression with lymph nodemetastasiswas higher than that without lymph node metastasis(57. 9%vs22. 2%,P0·01). The positive rate ofVEGF-C expression with lymph nodemetastasis was higher than that without lymph nodemetastasis(68. 4%vs25. 9%,P0·01). The positive expression ofCXCR4 was consistent with the positive expression of VEGF-C,and the expression levels ofCXCR4 and VEGF-C were closely correlated with lymph nodemetastasis, but notwith age, tumor size, histological type, cellulardifferentiation and invasion depth. Conclusion　CXCR4 and VEGF-C expressions may become predictors for the lymphaticmetastasis of breast carcinoma . 　　【Key words】 Chemokine receptor CXCR4; vascular endothelial growth fac