PROVE IT研究PPT课件.pptVIP

0115010821 Ballantyne MD Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT): Design 4162 patients hospitalized for ACS within previous 10 days, TC ?240 mg/dL (?200 mg/dL if on lipid Rx) Randomized to pravastatin 40 mg (standard therapy) or atorvastatin 80 mg (intensive therapy) Primary endpoint: composite of death, MI, unstable angina requiring rehospitalization, revascularization (at least 30 days after randomization), and stroke Follow-up: 18–36 months (mean, 24) PROVE IT: Baseline Characteristics PROVE IT: Lipid and CRP Changes PROVE IT: LDL-C Achieved PROVE IT: Ef