功能材料1课件.pptVIP

汇 报 人：宁漂 2015.12.21 conclusions 4 Synthesis 2 3 Introduction 1 background proteins or microorganisms could easily adhere to implanted hydrogels and form biofouling films, not only blocking the circulation of loaded biomolecules but also triggering an immune response or inflammation. Mussel-Inspired Marine mussels secrete foot proteins which after a curing process can form byssus consisting of proteinaceous thread and adhesive plaque to adhere to various substrates underwater,The self-repair of mussel byssal threads is mainly attributed to the reversible metal-catechol coordination between metals like Fe 3+ and catechol groups from an amino acid called 3,4-dihydroxyphenyl- L -alanine (DOPA), and other interactions like cation- π interaction can also play a role. Temperature-responsive storage and To rule out the possibility that thermal-induced gelation was due to cathechols’ coupling reactions after oxidation. essential of the hydrogel Theself-healing mechanism fluorescence microscopy images of uncoated and DNODN hydrogel coated microwell dishes after exposureto Caco-2 cells for 48 h are shown to demonstrate exceptional antifouling performance against cell attachment of The DNODN hydrogel。 1、 we have developed a novel injectable thermosensitive self-healing hydrogel DNODN with anti-biofouling property. 2、 The thermosensitive property and shearing thinning behavior of the hydrogel allow it injectable in vivo at body temperature. 3 、the anti-biofouling properties can effectively inhibit the formation of biofilms. 4、The self-mending DNODN hydrogel can withstand high strain and repeated deformation and quickly recover its mechanical properties 5、 structure through the catechol-mediated reconstruction of hydrogen bonding and aromatic interactions, thus reducing the infl ammation risk in bioengineering applications Thanks 实验条件 特征黏度：1.86dL/g 浸渍浓度：10、30、 50、 70、90、110mg/L 浸渍时间：15min 浸渍温度：20℃ 作用对象：金黄色葡萄球菌 单层纱布 染菌24h 4.1 PDADMAC浸渍浓度的