微小RNA和其心血管病理生理学作用1.docVIP

微小RNA及其心血管病理生理学作用 【摘要】? 微小RNA是近年发现的内源性非编码RNA小分子，主要在转录后水平调控基因表达，参与包括发育、肿瘤生成、病毒性疾病、免疫性疾病在内的多种生理及病理生理过程。微小RNA在心血管系统中也具有广泛的生物学作用。本文将就微小RNA在心血管病理生理中的作用作简要介绍。 MicroRNAs (miRNAs) are endogenous noncoding RNAs discovered in recent years that posttranscriptionally regulate the gene expression. They are implicated in various biological processes including development, oncogenesis, viral and immunological diseases. Many miRNAs are highly expressed in the cardiovascular system and play an important role in cardiovascular health and diseases. In this paper, we briefly review the recent understanding of miR