肿瘤治疗电场研析进展及其展望.pdfVIP

Med J Chin PLA, Vol. 39, No. 1, January 1, 2014 　75 肿瘤治疗电场的研究进展及展望 韩睿，林洪生 [摘要]　Nov oTTF- 100A 装置是20 11年获FDA 批准，可用于临床治疗成人复发多形性胶质母细胞瘤(RGBM ) 的新型 治疗手段，亦称肿瘤治疗电场(TTFi el ds) 。该装置可产生中频交变电场，诱导某些特定类型的癌细胞凋亡，且毒副作 用小。虽然该治疗手段发展前景广阔，但其作用机制仍未完全阐明。本文对TTFi el ds 的作用机制及应用进行综述，以 加深对该新技术的了解。 [关键词]　肿瘤治疗电场；Nov oTTF- 100A 装置；胶质母细胞瘤 [中图分类号]　R730.59　　　　[文献标志码]　A　　　　[文章编号]　0577-7402 (20 14 )0 1-0075-05 [DOI]　10. 11855/j.issn.0577-7402.20 14.0 1. 17 Progress and prospect of TTFields in the treatment of tumor * HAN Rui, LIN Hong-sheng Department of Oncology, Guanganmen Affiliated Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China * Corresponding author, E-mail: drlinhongsheng@163.com [Abstract]　Th e treatment of recurrent gliobl astoma multif orm in adults w ith dev ice Nov oTTF- 100A h as b een approv ed by US FDA in 20 11. This nov el treatment is also named as TTFields (tumor treating fields). It has b een prov ed that TTFields may induce ap optosis of some sp ecific cancer cells by prov iding a low intensity and intermediate frequency alternativ e electric fields w ith characteristics of non-tox icity, etc. Th e technique of TTFiel ds sh ow s a broad prosp ect on dev el opment, but th e mechanism of its effect remains unclear. This rev iew intends to rep ort a basic understanding by summarizing th e mechanism and clinical application of TTFields. [Key words]　tumor treating fields; dev ice Nov oTTF- 100A ; glioblastoma N ov oT T F - 10 0A 系统是一种便捷、可佩戴，并对 细胞，但其在细胞膜上所产生的更强的去极化作 [1-2] 患者一般日常活动无影响的新型肿瘤治疗设备 ，具 用会因为刺激被综合而不能产生动作电位。高于 有治疗多种癌症的潜力，简称肿瘤治疗电场(tum or 10MHz频率的电场会因真核细胞膜的电生理学特性