农药毒理学农药对人类的影响.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Basic Requirements of Toxicity Evaluation ? Subchronic 90-Day Feeding Study Rodent (Rat, Mouse)) Non-rodent (Dog) Dermal (Depending on Use Pattern) Inhalation Neurotoxicity VPHY8300/Spring 04 Basic Requirements of Toxicity Evaluation ? Chronic One- or Two-year Oral Study Rodent (Usually Rat) Non-rodent (Dog) Life-time Oncogenicity Study Reproductive Multi-generation (Rat, Mouse), Fertility, Reproduction