热毒和血栓形成关系的实验及其临床的研究.pdfVIP

Experimental and Clinical Research on The Relationship of Heat-Toxin and Thrombosis Speciality: Internal Medicine of TCM Author: Peng Min Tutor: Professor Ding Shuwen Abstract Theoretical study elucidates that heat-toxin play an important role in the pathogenesis of acute coronary syndrome, it is the initial factor of thrombosis, and the target position is collateral. Hereby establish therapeutic principle of clearing heat, dispelling toxin and dredging collateral, and then validate the curative effect of Dispelling toxin and dredging collateral mixture on thrombosis through experimental and clinical research. Animal experiment observed the effect of Dispelling toxin and dredging collateral mixture on thrombisis. Carrageen used to make the tail thrombus model, measured the length of black tail at different time and examed the activeness of AT-III and the content of D-dimer, as well as the content of inflammatory factor IL-1β、TNF-α. Drew conclusion that Dispelling toxin and dredging collateral mixture had the function of alleviating the thrombus caused by carrageen. Through preventive administration, Dispelling toxin and dredging collateral mixture can decrease the value of IL-1β and TNF-α, inhibit the inflammatory reaction, also can enhance the activity of AT-Ⅲ and reduce the content of D-dimer, thus alleviate thrombosis. The middle dose of Dispelling toxin and dredging collateral mixture is found the optimal dose to be effective. Clinical research observed the effect of Dispelling toxin and dredging collateral mixture on unstable angina. The control group ，45 patients ，treated with the routine therapy, while the test group ，48 patients ，added Dispelling toxin and dredging collat