小动物PET成像研究传统复方中药通心络神经保护作用.docVIP

小动物PET成像研究传统复方中药通心络的神经保护作用 通心络在中国已广泛用于急性脑卒中的治疗，并证明其对缺血再灌注损伤后的血脑屏障有保护作用。来自中国广东省中医院脑病中心的程骁博士所在课题组，在大鼠脑缺血再灌注前5天，连续给予通心络灌胃干预。应用小动物PET研究中药复方通心络预处理对对脑缺血再灌注损伤的神经保护作用。小动物PET用于药物研究的优势在于：（1）相对于体外实验，其检查结果与临床更为接近。（2）小动物PET成像可以在同一只动物身上重复完成，从而减少实验动物的使用，节省实验费用。（3）最大的优势在于可研究同一只动物在不同时间点的脑代谢变化，从而排除种属间差异。（4）结果说明，小动物18F-氟脱氧葡萄糖正电子发射断层扫描Article: Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats by Xiao Cheng1, Haoxuan Luo2, Lihua Zhou2, Lixin Wang1, Jingbo Sun1, Yan Huang1, Enli Luo1, Yefeng Cai1 (1 Encephalopathy Center, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China; 2 Department of Anatomy, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong Province, China) Cheng X, Luo HX, Zhou LH, Wang LX, Sun JB, Huang Y, Luo EL, Cai YF. Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats. Neural Regen Res. 2014;9(13):1267-1274. 欲获更多资讯 Neural Regen Res Neuroprotective effect of Tongxinluo: a PET imaging study in small animals Tongxinluo has been widely used in China for the treatment of acute stroke and for neuroprotection. Research group at Encephalopathy Center, Guangdong Provincial Hospital of Traditional Chinese Medicine, China intragastrically administered Tongxinluo superfine powder suspension or its vehicle to rats for 5 successive days before middle cerebral artery occlusion. There are many advantages of using small animal PET for drug research. First, the results of the study in vitro cannot be directly applied to human studies, while small animal PET imaging methods and results can be extrapolated to humans, thus bridging animal and human studies. Moreover, with PET imaging, experimental procedures can be repeated in the same animals without damage, thus reducing the use of laboratory animals, improving ethical acceptability and saving experimental costs. The biggest scientific advantage of small animal PE