W8-自身免疫教程分析.ppt

Experimental autoimmune encephalomyelitis (EAE) T cells specific for myelin basic protein mediate EAE: Inflammation in the nerve system Th1/Th17 responses Adoptive transfer of specific CD4 T cells IFNg/IL-17 Tumor antigen - using immune response to attack antigen specific tumors Prevention, Therapy Diagnosis Tumor Immunity Transplantation antigens Immune mechanisms of graft rejection Pathological mechanisms of graft rejection Prevention of graft rejection Transplantation Immunity * * Good pastures Syndrome 症状和诊断 呼吸急促、咳嗽；肾功能迅速衰竭. 可能会有少量的血尿.。 化验结果 血液中特有的抗体； 血液和尿液检查发现尿蛋白；贫血. 胸部X光异常(因肺部出血)， 肾脏组织穿刺针切片显示抗体沉淀 Good pastures Syndrome Deposition of auto-antibodies reactive with glomerular basement membrane and collagen VI. Wegener‘s granulomatosis Characterized by inflammation in a variety of tissues Primarily affects the upper respiratory tract, lungs, kidneys. Other organ can also be affected: the nervous system, ears, eyes, heart, and skin. Serum from patients with Wegener‘s granulomatosis contains autoantibodies reactive with neutrophil cytoplasmic granules (ANCA) Graves‘ disease 甲状腺机能亢进 Myasthenia gravis 重症肌无力 Graves‘disease 垂体 TSH 甲状腺 TH Antibody (aTSH-receptor) TSH-Receptor TH (-) 垂体 甲状腺 Myasthenia gravis 抗乙酰胆碱受体的自身抗体 Immune complex-mediated disease Disease Antigen Pathology Systemic lupus erythematosis DNA, nucleoprotein Nephritis, arthritis, vasculitis Post-straptococcal glomerulonephritis Straptococcal cell wall Nephritis Rheumatoid arthritis IgG arthritis Systemic Lupus Erythematosis (SLE) Deposit of immuncomplexes in glomerulus T cell-mediated disease Disease Antigen Pathology Insulin-dependent diabetes mellitus Pancreatic ?-cell ?-cell destruction Multiple sclerosis (mouse: experimental autoimmune encephlomyelitis, EAE) Myelin basic protein PLP MOG Brain invation by CD4 T cells, weakness Rheumatoid arthritis Synovial joint Joint inflammation and destruction Multiple Sclerosis MS patients can have autoantibodies and/or self reactive T cells whi