Skinbiology(CN)教程.ppt

* * * * * * * * * * Cells Types细胞种类 Fibroblasts成纤维细胞 Mast cells肥大细胞 Histiocytes组织细胞 Cells Types细胞种类 Fibroblasts成纤维细胞 Most abundant cells in dermal layer 真皮层中最多的细胞 Produce more than one type of collagen elastic fibers all at the same time 同时产生多种胶原弹性纤维 Flat, elongated, connective tissue cells 扁平细长的结缔组织细胞 Responsible for tissue synthesis and degradation 负责组织的合成和降解 Cells which colonize acellular dermal replacements for burns/wounds 细胞增殖，修复创伤 Cells Types细胞种类 Mast Cells肥大细胞 Important role in inflammation in immediate hypersensitivity reactions (allergies) 在炎症即发过敏反应(变态反应)中起到重要作用 Clustered around blood vessels in fat tissue 聚集在血管周围脂肪组织中 Release of bradykinin histamine 释放缓激肽组胺 Results in erythema (redness) and edema (swelling) 导致红斑和水肿 Cells Types细胞种类 Histiocytes 组织细胞 Scattered among fibers of dermis 分散在纤维和真皮中 Termed “fixed macrophages” since they stay in same place rather than migrate 被称为固定巨噬细胞，因其固定在同一位置，不移动 Phagocytose cell fragments, bacteria other debris 吞噬细胞碎片，细菌和其他残骸 Function of the Dermis 真皮的功能 防护身体撞击 提供氧气，水分和营养 通过血液带走表皮新陈代谢产物 供给身体外形 提供肤色，特别是对表皮很少黑色素的人 通过血液流动和排汗调节体温 触感，痛感，热感和冷感 The Hypodermis 皮下组织 The hypodermis is the lowermost layer of the skin. 皮下组织在皮肤最底层 Types of cells that are found in the hypodermis are细胞类型为 Adipocytes 脂肪细胞 contain a large lipid droplet surrounded by a ring of cytoplasm. 含有大量脂肪滴环绕着细胞质 Fibroblasts 成纤维细胞 Macrophages 巨噬细胞 The hypodermis is used mainly for fat storage. 皮下组织用于储存脂肪 The cell organisation 细胞组织结构 (6) Golgi apparatus 高尔基体 (8) smooth ER 平滑内质网 (9) Mitochondria 线粒体 (11) Cytoplasm 细胞质 (1) DNA (2) Nucleus 细胞核 (3) Ribosome 核糖体 (5) rough endoplasmic reticulum (ER) 粗面内质网 * Collagen 胶原蛋白 Integrin 整联蛋白 Fibronectin 纤维连接蛋白 Proteoglycan 蛋白聚糖 细胞间质 Any questions? * * * * * * * * * Stratum corneum: 10-20 anucleated keratinized cell layers (corneocytes) 10 -20 无核的角质化细胞层 3-4 layers in thin skin ~15 mm thick depending on body location and hydration Flattened non-nucleated cells