Acromegaly肢端肥大症技术分析.docx

Acromegaly Description enlargement of hands, feet, and facial features due to excess growth hormone secretion by pituitary gland or ectopic source Types types of pituitary adenomas causing?acromegaly?include( HYPERLINK /dynamed/detail?vid=2sid=95e55556-9415-4d51-a5fd-bde6a13ae196%40sessionmgr4002hid=4206bdata=JnNpdGU9ZHluYW1lZC1saXZlJnNjb3BlPXNpdGU%3d \l anc-958835675 1) benign monoclonal growth hormone-secreting pituitary adenoma surrounded by normal pituitary tissue found in 90% of patients with?acromegaly slow growing patients usually 50 years old rapidly growing, sparsely granulated adenomas made up of growth hormone-secreting cells patients typically younger 25% of growth hormone adenomas also secrete prolactin primitive acidophil stem cell adenomas more common in teenagers often causes? HYPERLINK /dynamed/linklist/GetRecord?sid=95e55556-9415-4d51-a5fd-bde6a13ae196@sessionmgr4002vid=2theTerm=AN\o gigantism gigantism pathology consistent with mixed single cellular or multicellular plurihormonal immunoreactivity may be called?acromegaly?with onset after puberty and gigantism with onset before puberty( HYPERLINK /dynamed/detail?vid=2sid=95e55556-9415-4d51-a5fd-bde6a13ae196%40sessionmgr4002hid=4206bdata=JnNpdGU9ZHluYW1lZC1saXZlJnNjb3BlPXNpdGU%3d \l anc-958835675 1) Who is most affected no apparent differences in race, gender, or ethnicity among affected individuals( HYPERLINK /dynamed/detail?vid=2sid=95e55556-9415-4d51-a5fd-bde6a13ae196%40sessionmgr4002hid=4206bdata=JnNpdGU9ZHluYW1lZC1saXZlJnNjb3BlPXNpdGU%3d \l anc-1218555223 5) mean age at presentation 44 years ( HYPERLINK /pubmeddopt=Abstract \t %5Fblank Pituitary 1999 Jun;2(1):29) Incidence/Prevalence: incidence about 3-4 per million per year and prevalence 60 per million population reported in reviews( HYPERLINK /dynamed/detail?vid=2sid=95e55556-9415-4d51-a5fd-bde6a13ae196%40sessionmgr4002hid=4206bdata=JnNpdGU9ZHluYW1lZC1saXZlJnNjb3BlPXNpdGU%3d \l anc-958835675 1,? HYPERL