重组人血管内皮抑素治疗恶性浆膜腔积液的疗效分析.pptVIP

有关积液与VEGF的相关性,我们的魏博士后已经进行了大量的工作。VEGF水平对良恶性的判断以及与疾病的分期有关。 2000 pg/ml诊断的敏感性为71.7%,特异性为76.0%. We developed a novel mouse model of MPE by injecting Lewis lung carcinoma (LLC) cells directly into pleural cavity of C57BL/6 mice. To evaluate the therapeutic eVects of endostatin in this MPE model, we injected the Ad-hEndo into the pleural cavity of MPE-bearing mice three times with the 3-day interval. 2008-12~2011-01 重组人血管内皮抑素治疗恶性浆膜腔积液的疗效分析 恶性胸腔积液概况 malignant pleural effusion (MPE) 美国 150,000 ↑ 英国 40,000 ↑ Am J Clin Oncol 2010;33: 420–423 恶性腹腔积液概况 malignant ascites 恶性浆膜腔积液形成机制 ↓ ↓ ↓ ↑ ↑ ↑