小细胞肺癌详细分析.ppt

介绍Introduction 2004 WHO 将肺癌分为两个主要组织学类型: 非小细胞肺癌 和小细胞肺癌 。SCLC 占肺癌总数的 13%-15%，是最常见的原发性肺神经内分泌肿瘤 。 The 2004 World Health Organization (WHO) classification scheme divides lung cancer into two major histologic categories: non–small cell lung carcinoma (non-SCLC) and SCLC，SCLCs account for 13%–15% of all lung cancers and are the most common primary pulmonary neuroendocrine neoplasm。 在所有组织类型中，小细胞肺癌的发病与吸烟关系最为密切，大约95%的小细胞肺癌患者有吸烟史。 and of all the histologic subtypes of lung cancer, SCLC has the strongest association with cigarette smoking. 介绍Introduction 小细胞肺癌特点是肿瘤细胞倍增时间短，增殖指数高，比非小细胞肺癌更具侵略性，并有早期广泛转移的倾向。 SCLC is more aggressive than non-SCLC and is characterized by a rapid doubling time, high growth fraction (the ratio of proliferating cells to total cells), and greater propensity for early development of widespread metastases 介绍Introduction 美国老年委员会肺癌研究小组(VALSG) 制定的分期系统将小细胞肺癌分为局限期和广泛期。不过现在已经被修订的TNM分期方法所代替。 SCLC is usually categorized according to a modified version of the Veterans Administration Lung Cancer Study Group (VALSG) staging system as either limited-stage SCLC (LS-SCLC) or extensive-stage SCLC (ESSCLC). 介绍Introduction 准确的分期对小细胞肺癌患者的治疗有指导性意义，放疗和化疗联合治疗对局限期小细胞肺癌是有效果的，其中一小部分患者能长期存活。 Accurate staging of patients with SCLC helps guide individual treatment strategies, since patients with LS-SCLC are candidates for curative-intent chemotherapy– radiation therapy, a small percentage of whom experience long-term survival. 介绍Introduction 在本文献中，我们主要是复习小细胞肺癌的病理及它的发展，并讨论CT 和 PET -CT 对患者疾病的分期和评价。 In this article, we review the pathophysiology and natural history of SCLC and discuss the role of computed tomography (CT) and 2-[fluorine-18]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/CT in the evaluation and staging of patients with the disease. 肺神经内分泌肿瘤的分类 Classification of Pulmonary Neuroendocrine Neoplasms WHO将肺神经内分泌肿瘤分为3个病理等级 以及4个分类： 低度恶性：典型类癌肿瘤； 中间级肿瘤：不典型类癌； 高度恶性肿瘤：包括大细胞神经内分泌肿瘤以及小细胞肺癌。 在这篇文章，我们专注于小细胞肺癌。 The 2004 WHO tumor classification scheme incl