卵泡穿刺结合人工授精治疗未破裂卵泡黄素化综合征所致不孕-论文.docVIP

卵泡穿刺结合人工授精治疗未破裂卵泡黄素化综合征所致不孕 【摘要】 目的 探讨卵泡穿刺联合宫腔内人工授精在治疗卵泡未破裂黄素化所致不孕症中的临床效果。方法 将60例未破裂卵泡黄素化综合征患者随机分为两组, 研究组(35例)采用促排后卵泡穿刺结合夫精人工授精;对照组(25例)患者药物促排卵后指导同房。观察两组患者的妊娠率。结果 卵泡穿刺组临床妊娠率为371%,对照组临床妊娠率为160%(P001)。结论 经阴道卵泡穿刺术联合人工授精治疗,有助于提高未破裂卵泡黄素化综合征患者的妊娠率,是治疗LUFS所致不孕的有效方法之一。 　　【关键词】 　　未破裂卵泡黄素化综合征;卵泡穿刺;宫腔内人工授精 　　Treatment of follicular aspiration and intrauterine insemination in infertile women with luteinized unruptured ovarian follicle syndrome 　　LIN Chunlian Qinzhou Maternal and Child Health Hospital Fertility Center,Guangxi 53500,China 　　【Abstract】 Objective To investigate the effects of the combined follicular aspiration and intrauterine insemination (IUI) for treating for patients with luteinized unruptured ovarian follicle syndrome (LUFS) Methods60 cases of LUFS were divided into two groups randomly 35 cases (Experiment group) received ovulation stimulants and artificial fertilization; 25 cases (Control group) received ovulation stimulants and natura1 fertilization The ovulation rate in two groups was recorded and compared ResultsThe ovulation rate in experiment group was significantly higher than that in control group (371% vs 160%, P001)Conclusion Combined follicular aspiration and IUI is effective in treatment of LUFS patients, which can increase the rate of ovulation 　　【Key words】 　　Luteinized unruptured ovarian follicle syndrome; Follicular aspiration; Intrauterine insemination 　　未破裂卵泡黄素化综合征(Luteinized Unruptured Follicle Syndrome,LUFS) 是无排卵性月经的一种特殊类型,也是导致不孕的常见原因,其发生率在有生育力的妇女中约为5%～10%,在不孕症妇女中约为9%～55%,而在使用克罗米芬(CC) 促排卵患者中LUFS的发生率增高[1]。其发病机制尚不完全清楚。本文对35例LUFS致不孕的妇女81个周期进行卵泡监测, 成熟后进行穿刺以释放卵子,同时行人工授精;另外选取25例LUFS致不孕妇女58个周期做为对照组,对照组患者药物促排卵后,未做卵泡穿刺,并指导同房。 　　1 资料与方法 　　11 一般资料 　　 选择2008年5月至2009年11月在本中心就诊的患者中筛选出LUFS患者60例,其年龄为26～41岁,平均为(285±53)岁;不孕年限为2～9年,平均为(57±23)年。LUFS的诊断符合诊断标准[2]。所有研究病例均采用子宫输卵管碘油造影术检查,排除生殖道感染因素、免疫性不孕因素、输卵管及盆腔粘连所致的不孕,男方精液检查正常。将所有患者随机分为2组,卵泡穿刺组35例:年龄为28～41岁, 平均为(306±38)岁;不孕年限为2～10年, 平均为(48±16)年;对照组25例:年龄为24～38岁, 平均为(29