分子细胞生物学前沿-博士-2010资料.ppt

分子细胞生物学专题----转录延伸因子P-TEFb及其活性调控;Main Points;I. Transcription process;Steps of class II gene transcription;TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH RNA polymerase II (Pol II);RNA polymerase II (Pol II);Pre-initiation;PIC;Pol II;Pol II;Early elongation;Splicing;CycT1;Steps: Pre-initiation Initiation Promoter clearance Elongation Termination ;P-TEFb, its functions and activity regulation;P-TEFb: composition and property ;Physiological functions;;B. Pathological functions;TAR RNA;Trans-cyclin T1 gene causes cardiac hypertrophy;CycT1;LARP7;;P;CycT1;CycT1;How does cell signaling control the