难治性哮喘T探索.ppt

转录因子NF-E2相关因子2（Nrf2） Nrf2是氧化应激基本表达的关键基因 基质金属蛋白酶（MMP）-9 过敏性支气管肺真菌病 allergic bronchopulmonary mycoses (ABPM) 阿司匹林加重呼吸系统疾病 aspirin-exacerbated respiratory disease (AERD) 过敏性支气管肺曲霉菌病 Allergic Bronchopulmonary Aspergillosis（ABPA） 有关哮喘表型和内型的原文摘要解释如下： A phenotype is defined as the integration of different characteristics that are the product of the interaction of the patient’s genes with the environment. Both clinical and statistical approaches have identified at least 3–5 phenotypes of severe asthma. However, these phenotypes, in isolation, do not identify the immunopathology that makes these clinical phenotypes distinct or identifies a target population for a specific approach to therapy. As biological characteristics are identified, phenotypes should continue to evolve towards asthma endotypes. The identification of these endotypes, either by matching biology, genetics and therapeutic responses to therapy with clinically or statistically defined phenotypes or through unbiased genetic and genomic approaches, remains limited. * exercise-induced asthma (EIA) 运动诱发型哮喘 aspirin-exacerbated respiratory disease (AERD) 阿司匹林加重呼吸系统疾病 Paucigranulocytic asthma 粒细胞缺乏型哮喘 原文出处：even ‘paucigranulocytic’ (the absence of an observable inflammatory process) were all suggested as asthma phenotypes, but few corresponding clinical and biological characteristics were identified. 这张图表的原文注释：Theoretical grouping of emerging asthma phenotypes based on the distinction between TH2-high asthma and non-TH2 asthma. TH2 asthma consists of both early- and later-onset disease over a range of severities. It is likely that the majority of early-onset allergic asthma is mild but that an increasing complexity of immune processes leads to greater severity. Later-onset eosinophilic asthma without traditional allergic elements is more likely to be severe, whereas EIA is a milder form of TH2 asthma. Non-TH2 asthma includes very late–onset, obesity-associated asthma as well as smoking-related and neutrophilic a