复方嗜酸乳杆菌在根除幽门螺杆菌感染中的疗效评价.doc

复方嗜酸乳杆菌在根除幽门螺杆菌感染治疗中的疗效评价 唐捷1，龙云1，苏强1，谭光林2 （1、南充市中心医院药剂科·川北医学院第二临床医学院，2、南充市中心医院急诊科 四川南充 637000） 摘要 目的：对复方嗜酸乳杆菌联合标准三联疗法治疗幽门螺杆菌感染性消化道溃疡的疗效进行评价。方法：选择2014年来本院就诊的经13C—尿素呼气实验（13C—UBT）或经胃黏膜活检快速尿素酶实验 RUT 及电子胃镜检查确诊为幽门螺杆菌感染的患者240例，依病例入选先后次序按随机数字表法随机分为对照组和治疗组，对照组112例，治疗组128例。对照组给予传统的三联疗法（雷贝拉唑+阿莫西林+克拉霉素），治疗组在传统三联疗法的基础上加用复方嗜酸乳杆菌，疗程均为14d。治疗结束4周后对患者进行复诊，详细记录患者临床症状缓解率、溃疡愈合率、Hp根除率及不良反应。结果：治疗结束4周后治疗组与对照组的临床症状缓解率分别为90.6%、76.8%；溃疡愈合率分别为92.2%、74.1%；Hp根除率分别为91.6%、73.2%；不良反应发生率对照组与治疗组分别为27.7%、11.7%，2组疗效及不良反应均有显著性差异（P 0.05）。结论：复方嗜酸乳杆菌联合三联疗法可显著提高标准三联疗法的Hp的根除率，促进溃疡愈合，降低不良反应，是治疗Hp感染性溃疡的安全有效的新途径。 关键词：复方嗜酸乳杆菌；幽门螺杆菌；消化道溃疡；三联疗法；疗效评价 Compound lactobacillus acidophilus in the eradication of helicobacter pylori infection treatment curative effect evaluation TANG Jie，LONG Yun，SU Qiang,TAN Guanglin （The Second Clinical medical College of North Sichuan Mmedical College·Pharmacy Department of Nanchong Central Hospital,Sichuan Nanchong 637000,China） ABSTRACT Objective: The compound lactobacillus acidophilus combined standard triple therapy to evaluate the curative effect of treatment of helicobacter pylori infection peptic ulcer. Method: Choose 2014 years in our hospital clinic of the 13 c - urea breath test UBT 13 c - or by gastric mucosa biopsy, rapid urease test RUT and electronic gastroscopy diagnosis of helicobacter pylori infection of 240 cases of patients, according to the cases in order according to random number table method were randomly divided into control group and treatment group, control group 112 cases, the treatment group 128 examples. The control group given conventional triple therapy rabeprazole azole, amoxicillin and clarithromycin , the treatment group on the basis of traditional triple therapy combined with compound lactobacillus acidophilus, a course of 14 d. End of 4 weeks after treatment for patients with appointment, detailed record patients clinical symptom remission rate, ulcer healing rate, Hp eradicate rate and adverse reactions. Results: After 4 weeks of treatment gr