糖尿病领域专利技术申请资料汇编（九）.doc

糖尿病领域专利技术申请资料汇编（九） 申请(专利权)人 济南帅华医药科技有限公司Jinan Shuaihua Pharmaceutical Technology Co Ltd 发明(设计)人 孙 娟Sun Juan 国际专利分类码 A61K 09/00 A61K 09/08 A61K 09/10 A61K 31/7036 A61K 47/34 A61P 31/04  专利局: 中国知识产权局中文专利 (SIPO) ?? 标题: 一种含核糖霉素的缓释注射剂 一种含核糖霉素的缓释注射剂  申请编号: 200810301564.3 公开编号: 101278904 申请日期: 2006-05-17 公开日期: 2008-10-08 摘要 一种含核糖霉素的缓释注射剂由缓释微球和溶媒组成，缓释微球含缓释辅料和氨基糖苷类抗菌素，溶媒为含羧甲基纤维素钠等助悬剂的特殊溶媒，黏度为100cp-3000cp(20-30℃时)；缓释辅料选自EVAc、聚苯丙生、PLA、PLGA、癸二酸共聚物、蛋白胶、明胶等；缓释微球也可制成缓释植入剂和软膏剂。缓释植入剂和缓释注射剂在菌灶局部放置或注射能将药物在局部缓慢释放5到30天以上，在有效获得和维持局部灶有效药物浓度的同时明显降低其全身毒性。对葡萄球菌属、链球菌属、消化链球菌属、痤疮丙酸杆菌、肠杆菌属、结核杆菌、淋球菌或脑膜炎球菌等引起的局部感染病灶如慢性骨髓炎、重症褥疮、顽固性皮肤溃疡、糖尿病足、股骨头坏死和各种脓肿等具有显著独特的治疗效果。The invention relates to a slow-released injection comprising ribostamycin, which comprises a slow-released microsphere and a dissolvent; the slow-released microsphere comprises a slow-release adjuvant and the aminoglycoside antibiotic; the dissolvent is the special dissolvent which comprises a suspending agent such as sodium carboxymethylcellulose, etc., and the viscosity of which is 100cp-3000cp (at 20 DEG C-30 DEC C); the slow-release adjuvant can be selected from EVAc, polifeprosan, PLA, PLGA, sebacic acid copolymer, albumen glue and gelatin, etc.; the slow-released microsphere also can be made into a slow-released implant and an ointment. The slow-released implant and the slow-released injection can be partially placed or injected in a bacterial focus to release locally and slowly for more than 5-30 days, thereby obviously reducing the toxicity of the entire body while getting and maintaining a valid medicine density in the local focus effectively. The slow-released injection comprising the ribostamycin of the invention has obvious special treatment effect for focus of local infection such as chronic osteomyelitis, severe bedsore, refractory skin ulcer, diabetic foot, osteonecrosis of femoral head and various abscesses, etc., caused by staphylococcus, streptococcus, peptostreptococcus, propioni