缺氧导致的病理性血管再生与肿瘤迁移.pptVIP

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model Hypoxia—VEGF—Angiogenesis—Metastasis 概要 Mechanisms underlying pathological angiogenesis in relation to hypoxia in tumor invasion and metastasis remain elusive. Tumor microvascular networks possess several unique pathological features including extremely high densities of leaky, tortuous, and primitive microvessels that usually lack pericyte coverage, base-ment membrane, and arteriole-venule distinctions . Although hypoxia often results in necrosis of the central c